- Cdh1 Mutants
- cdh1∆
- sic1∆ cdh1∆
- sic1∆ cdh1∆ GALL-CDC20
- sic1∆ cdc6∆2-49 cdh1∆
- sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20
- cdh1∆ cdc6∆2-49
- swi5∆ cdh1∆
- swi5∆ cdh1∆ GAL-SIC1
- cln1∆ cln2∆ cdh1∆
- GAL-CLN2 cln1∆ cln2∆ cdh1∆
- cln1∆ cln2∆ cln3∆ cdh1∆
- GAL-SIC1 cln1∆ cln2∆ cdh1∆
- GAL-SIC1 GAL-CLN2 cln1∆ cln2∆ cdh1∆
- CLB1 clb2∆ cdh1∆
- GAL-CLB2 cdh1∆
- GAL-CLB5 cdh1∆
- cdc14-ts cdh1∆
- cdc15∆ net1-ts cdh1∆
- APC-A cdh1∆
- APC-A cdh1∆ in galactose
- APC-A cdh1∆ GAL-SIC1
- APC-A cdh1∆ GAL-CDC6
- APC-A cdh1∆ multi-copy SIC1
- APC-A cdh1∆ multicopy CDC6
- APC-A cdh1∆ multicopy CDC20
- Cdh1 constitutively active
GAL-CLB5 cdh1∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: ksb5'=0.012, kscdh=0, MDT=150, init CDH1=CDH1T=0
Length of G1 phase: 126 min.
Mass at division: 1.36.
Experiments:
Chen, K.C., Calzone, L., Csikasz-Nagy, A., Cross, F.R., Novak, B. and Tyson, J.J. (2004). Integrative analysis of cell cycle control in budding yeast. Mol. Biol. Cell 15:3841-3862.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Inviable.
webmaster
His observation: "Although the mutant is ultimately inviable or extremely slow-growing on galactose, this is not associated with any obvious problems in a short-term experiment. These cells clearly go through several doublings, probably without much difficulty, on galactose medium, and they remain reasonably viable when returned to glucose, like GAL-CLB5 cells. The DNA profile looks like that of GAL-CLB5 controls, mostly 2C DNA. So I think at the level of a computational model, it is not reasonable to expect the model to predict inviability of GAL-CLB5 cdh1∆ mutants. They should probably look pretty viable".